SCHEDULE |
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| DATE | OPPONENT | CLASS | LOCATION | VAR TIME | RESULT | SCORE | PTS |
| 12/1/2021 |
West Seneca West
|
A | Lancaster HS | 7:00 PM | W | 77-38 | 4.0 |
| 12/3/2021 |
Depew
|
B | Lancaster HS | 7:00 PM | W | 54-24 | - |
| 12/8/2021 |
Amherst
|
A | Lancaster HS | 7:00 PM | L | 40-56 | - |
| 12/19/2021 |
at Bishop Kearney
|
AA | Bishop Kearney High School | CANCELLED | - | ||
| 12/27/2021 |
at Health Sciences
|
A | St. Francis High School | 6:00 PM | L | 28-35 | - |
| 12/28/2021 |
at Williamsville East
|
A | St. Francis High School | 6:00 PM | L | 77-87 | - |
| 1/4/2022 |
at Williamsville North
|
AA | Williamsville North HS | 7:30 PM | W | 56-28 | 5.0 |
| 1/10/2022 |
at Orchard Park
|
AA | Orchard Park HS | 7:30 PM | L | 55-67 | 0.0 |
| 1/12/2022 |
Jamestown
|
AA | Lancaster HS | 7:45 PM | L | 49-57 | 0.0 |
| 1/15/2022 |
at Clarence
|
AA | Clarence HS | 11:30 AM | W | 45-40 | 5.0 |
| 1/18/2022 |
at Hamburg
|
A | Hamburg HS | 7:30 PM | L | 63-68 | 0.0 |
| 1/20/2022 |
Frontier
|
AA | Lancaster HS | 7:00 PM | L | 42-44 | 0.0 |
| 1/24/2022 |
Orchard Park
|
AA | Lancaster HS | 7:00 PM | L | 47-60 | 0.0 |
| 1/26/2022 |
at Bishop Kearney
|
AA | Bishop Kearney High School | 7:30 PM | L | 58-66 | - |
| 1/29/2022 |
Williamsville North
|
AA | Lancaster HS | 12:00 PM | W | 62-54 | 5.0 |
| 2/2/2022 |
at West Seneca West
|
A | West Seneca West HS | 7:30 PM | W | 86-54 | 4.0 |
| 2/7/2022 |
Clarence
|
AA | Lancaster HS | 7:00 PM | W | 48-45 | 5.0 |
| 2/10/2022 |
Hamburg
|
A | Lancaster HS | 7:00 PM | W | 52-26 | 4.0 |
| 2/12/2022 |
at Jamestown
|
AA | Jamestown HS | 7:00 PM | L | 56-58 | 0.0 |
| 2/15/2022 |
at Frontier
|
AA | Frontier HS | 7:00 PM | L | 56-57 | 0.0 |
| 2/18/2022 |
at Lockport
|
A | Lockport HS | 6:30 PM | L | 44-55 | - |
| 2/25/2022 |
at Clarence
|
AA | Clarence HS | 7:00 PM | W | 56-52 | - |
| 3/2/2022 |
at Jamestown
|
AA | Buffalo State College | 5:15 PM | L | 43-59 | - |